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if iron accumulation was one of the causes for its development. Oftentimes the storage protein for iron, ferritin, can reach the eye instead of the mineral itself. The result is hereditary hyperferritinemia cataract syndrome (hhcs an inherited condition of early-onset cataracts which could be dangerously confused with hemochromatosis (iron overload) unless a person is diagnosed using the full iron panel : Hemoglobin : the iron-containing protein in the blood that carries iron. An ophthalmologist confirms diagnosis of hhcs. While smoking, poor diet, and lack of exercise typically contribute to oxidation of the retina, research has found that iron may also increase a persons risk of AMD, according. Iron chelation therapy is the removal of excess iron from the body with special drugs. Iron accumulates in the body with age because we continue to absorb it from our diets, but we excrete very little, Dunaief said. Iron is a necessary mineral for many of the bodys functions, including vision. In hhcs, components of ferritin accumulate in the eye lens and crystalize disrupting the light transmission which enables a person to see.

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Attachment, posted on Mon, June 20, 2016 by Kayla Wiles. Iron contributes to the leading causes of vision loss. Deferiprone can protect the retinas of mice by entering the retina and removing iron from it, said Dunaief, whose lab is currently testing additional drugs to prevent iron accumulation in the eye. Transferrin-iron saturation percentage (TS) : a measure of iron carried by the protein transferrin in the serum; represented by fasting serum iron divided by total iron binding capacity (tibc multiplied by 100. Normally the RPE has ways to prevent iron from entering the retina when iron levels are high, but if iron export from cells is unregulated, iron may accumulate in the eye and degrade the macula.

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